From 19c3d0dba64d782e519d8ece36028ebb25b33141 Mon Sep 17 00:00:00 2001
From: Mike Vink <mike1994vink@gmail.com>
Date: Fri, 23 Apr 2021 17:30:09 +0200
Subject: demo table and fig

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 data_understanding/main.tex |  53 +++++++++++++++++++++++++++++++++++++++++---
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@@ -139,10 +139,22 @@ mining modelling process to replicate these results.
 
 In the work of \cite{tomicFluPRINTDatasetMultidimensional2019} data on
 indiviuals enrolled in influenza vaccine studies at the Stanford-LPCH Vaccine
-Program was collected, this data was archived at the Stanford Data Miner. This
+Program was collected, the data was archived at the Stanford Data Miner. This
 archive was filtered by assays used in influenza studies, resulting in data
 from 740 healthy donors, enrolled in influenza vaccine studies conducted by the
-Stanford-LPCH Vaccine Program from 2007 to 2015.
+Stanford-LPCH Vaccine Program from 2007 to 2015. These studies are described in
+the table accompanying the online publication of the fluprint dataset
+\autoref{tbl:studiesDesc}.  From those 740 donors a vaccine response
+classification was only given for 372 donors \autoref{fig:demoResponder}, by a
+method that will be described in the section describing the data table
+containing this attribute. Overall there was no major difference in demographic
+statistics when stratisfying the data in high or low responders
+\autoref{fig:demoResponder}.
+
+Importantly in all studies the donors are only vaccinated once, except in the
+study SLVP015, participants here were vaccinated annually from 2007-2015
+\autoref{tbl:studiesDesc}. In all other studies participants would only be
+studied within the scope of one influenza season.
 
 \fptable{studies_table}{.7}
 {Reference table of clinical studies}
@@ -152,7 +164,42 @@ rest of the columns.}
 {tbl:studiesDesc}
 
 
-i'm some text \autoref{tbl:studiesDesc}
+\begin{figure}
+    \includegraphics[width=\textwidth]{demographic}
+    \label{fig:demoResponder}
+    \caption{\textbf{A.} percentage of donors with factor property within high
+    and low responder groups. Included are sex, race, and CMV status
+    information. \textbf{B.} Age distribution of donors with a known response
+    classification.}
+\end{figure}
+
+\begin{table}
+\centering
+\begin{tabular}{ll}
+\toprule
+\textbf{Age (y)} & \\
+\midrule
+Mean $\pm$ SD & 21.02 $\pm$ 8.66\\
+Median (min. to max. range) & 22.5  ( 1 - 50 )\\
+\addlinespace
+    \textbf{Gender} & \\
+\midrule
+Male (\%) & 154 ( 41.4 )\\
+Female & 218  ( 58.6 )\\
+\addlinespace
+    \textbf{Ethnicity} & \\
+\midrule
+Caucasian (\%) & 187 ( 50.3 )\\
+African American (Black) (\%) & 4  ( 1.1 )\\
+Asian (\%) & 53  ( 14.2 )\\
+Hispanic/Latino (\%) & 5  ( 1.3 )\\
+Other (\%) & 121  ( 32.5 )\\
+Unknown (\%) & 2  ( 0.5 )\\
+\bottomrule{}
+\end{tabular}
+    \caption{\textbf{Demographic statistics of donors with known vaccine response classification.}}
+\end{table}
+
 
 \citep{chattopadhyaySinglecellTechnologiesMonitoring2014}
 The complex heterogeneity of cells, and their interconnectedness with each
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